Bajc M, et al. Eur J Nul Med Mol Imaging 2009; 36: 1356-1370
Bajc M, et al. Eur J Nul Med Mol Imaging 2009; 36: 1528-1538
"We recommend that SPECT/CT based quantification be used for all lung cancer patients undergoing pre-therapy evaluation of regional lung function."
Ventilation imaging is most often performed in conjunction with lung perfusion to characterize perfusion defects as a matched, mismatched or reverse mismatched.
The optimal tracer for ventilation studies is Technegas, an ultra fine dispersion of 99mTc-labeled carbon. Despite that Technegas is not approved for use in the United States, it is used in 79% of ventilation imaging studies performed in Canada and is also commonly used in Europe. Its main advantage is greater percentage deposition in the alveolar spaces and less undesirable adherence to the central airways, compared with droplet radioaerosols.
V/Q SPECT, using Technegas as the ventilation imaging agent, could diagnose and grade severity of COPD and also estimate preserved lung function in 94 patients. Moreover, V/Q SPECT appears to be a unique tool to reveal the heterogeneity of COPD caused by pulmonary comorbidities such as pulmonary embolism, left heart failure, lung tumor and pneumonia. The characteristics of these comorbidities suggest their significant impact in symptoms, their influence on prognosis and their response to treatment.
V/Q scintigraphy has affirmed its critical place in the evaluation of patients with lung cancer preparing for lung resection.
Enhanced by the advancements in hybrid imaging and computer processing, the V/Q scan examination continues to be reinvented and updated to keep pace with the needs of modern medicine.
Among the traditional imaging modalities for diagnosing pulmonary embolism (PE), the choice has narrowed to V/Q scan and CTPA. However, V/Q scan is preferred over CTPA for follow-up of PE particularly in young women in order to avoid the excessive breast radiation exposure associated with CTPA.
Pre-existing lung disease should not be a relative contraindication to the use of V/Q SPECT-CT. This modality has a sensitivity of 100% and specificity of 94% with lower radiation doses compared to CTPA.
99mTc-Technegas ventilation scintigraphy is an established and well-studied tool for imaging of lung ventilation and combined SPECT/CT has been shown to improve overall diagnostic accuracy in many areas of pulmonary nuclear medicine.
Compared to the currently available scanning technologies for diagnosing suspected PE, SPECT/CT appears to confer superior economic value, primarily via improved sensitivity and specificity and low non-diagnostic rates. In turn, the improved diagnostic accuracy accords this modality the lowest ratio of expenses attributable to potentially avoidable complications, misdiagnosis and underdiagnosis.
The introduction of the tomographic technique and the implementation of Technegas as a novel ventilation agent facilitated imaging of pulmonary embolism in comparison with planar imaging and particularly in COPD patients together with the new interpretation criteria.
Endoscopic lung volume reduction results in improved gas transfer capacity for at least 12 months. This may be explained by the ventilation-perfusion (V/Q) redistribution to the nontargeted and less emphysematous lung with improved VQ matching.